The impact of molecular classification on endometrial cancer management

Abstract

Introduction . Endometrial cancer is one of the most frequent gynecological cancers. Over the years, there has been more and more interest in the molecular characteristics of endometrial tumors that led to the molecular classification in 2013 of the endometrial cancer, with four molecular subtypes, with specific prognosis and treatment. Materials and method. We performed a narrative literature review in order to establish the changes that have been brought by the implementation of the molecular classification for endometrial cancer. We used the PubMed database, with a defined timed interval from 2013 to 2023, using the following keywords: “endometrial cancer”, “molecular classification”, “endometrial cancer management”. We selected the most appropriate articles which reflect our topic. Results . International societies have widely adopted the molecular classification and included it in algorithms in order to determine a risk classification. Further, staging and treatment options are based on these specific risk groups, which has led to shifts and changes to the way certain tumors were treated until now. Also, molecular classification has led the way to personalized treatment concerning adjuvant therapy. Conclusions . The introduction of molecular classification in clinical practice has made significant changes in endometrial cancer management, and important studies are ongoing, with the purpose of finding more therapeutic resources for every endometrial cancer subtype.