Biomarkeri utilizaţi în predicţia timpurie a diabetului gestaţional

Abstract

Objectives. The evaluation of maternal biomarkers that can guide us towards an early diagnosis of gestational dia­betes, as early as the first trimester of pregnancy, for a better management and to reduce potential adverse ef­fects of gestational diabetes on pregnancy and pregnant wo­men. Methodology. This article reviews research in the spe­cia­lized literature and aims to highlight how biomarkers, such as fasting glucose, HOMA score, glycated hemoglobin and PAPP-A, can constitute a set of parameters for screening ges­ta­tional diabetes as early as the first trimester of preg­nancy. Results. Women who developed gestational diabetes ex­hi­bi­ted higher values of biomarkers compared to patients un­af­fec­ted by this metabolic imbalance. Diagnosing ges­ta­tio­nal diabetes in the first trimester of pregnancy re­quires correlating multiple biological markers. Most stu­dies suggest that none of the markers used alone have a suf­fi­ciently high predictive value for screening gestational dia­betes in the first trimester. However, their correlation can quan­tify the risk of developing this condition and provide a clinical clue in routine practice.