Author:
Tommola Minna,Ilmarinen Pinja,Tuomisto Leena E.,Haanpää Jussi,Kankaanranta Terhi,Niemelä Onni,Kankaanranta Hannu
Abstract
The aim of this study was to evaluate the effect of smoking on lung function decline in adult-onset asthma in a clinical, 12-year follow-up study.In the Seinäjoki Adult Asthma Study, 203 patients were followed for 12 years (1999–2013) after diagnosis of new-onset adult asthma. Patients were divided into two groups based on smoking history: <10 or ≥10 pack-years. Spirometry evaluation points were: 1) baseline, 2) the maximum lung function during the first 2.5 years after diagnosis (Max0–2.5) and 3) after 12 years of follow-up.Between Max0–2.5 and follow-up, the median annual decline in absolute forced expiratory volume in 1 s (FEV1) was 36 mL in the group of patients with <10 pack-years of smoking and 54 mL in those with smoking history ≥10 pack-years (p=0.003). The annual declines in FEV1 % pred (p=0.006), forced vital capacity (FVC) (p=0.035) and FEV1/FVC (p=0.045) were also accelerated in the group of patients with ≥10 pack-years smoked. In multivariate regression analysis, smoking history ≥10 pack-years became a significant predictor of accelerated decline in FEV1.Among patients with clinically defined adult-onset asthma, smoking history ≥10 pack-years is associated with accelerated loss of lung function.
Funder
Finnish Anti-Tuberculosis Association Foundation
Tampere Tuberculosis Foundation
Jalmari and Rauha Ahokas foundation
The Research Foundation of the Pulmonary Diseases, Finland
The Competitive State Research Financing of the Expert Responsibility Area of Tampere University Hospital
The Medical Research Fund of Seinäjoki Central Hospital
Publisher
European Respiratory Society (ERS)
Subject
Pulmonary and Respiratory Medicine
Cited by
72 articles.
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