Author:
Chang De,Sharma Lokesh,Dela Cruz Charles S.
Abstract
Chitotriosidase (CHIT1) is a highly conserved and regulated chitinase secreted by activated macrophages; it is a member of the 18-glycosylase family (GH18). CHIT1 is the most prominent chitinase in humans, can cleave chitin and participates in the body's immune response and is associated with inflammation, infection, tissue damage and remodelling processes. Recently, CHIT1 has been reported to be involved in the molecular pathogenesis of pulmonary fibrosis, bronchial asthma, COPD and pulmonary infections, shedding new light on the role of these proteins in lung pathophysiology. The potential roles of CHIT1 in lung diseases are reviewed in this article.
Publisher
European Respiratory Society (ERS)
Subject
Pulmonary and Respiratory Medicine
Reference128 articles.
1. Chitinases from bacteria to human: properties, applications, and future perspectives;Rathore;Enzyme Res,2015
2. Ueber;Benecke;Sottfeitung Ant I,1905
3. De ontleding van chitine en zijn splitsingsproduct, het glucosamine, door bacterien. [The decomposition of chitin and its cleavage product, the glucosamine, by bacteria];Folpmers;Chem Weekbl,1921
4. Polysaccharide XXXIX. Über den enzymatischen Abbau von Chitin und Chitosan I.
5. Chitinolytic enzymes: an exploration
Cited by
28 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献