Minute ventilation/carbon dioxide production in chronic heart failure

Author:

Agostoni Piergiuseppe,Sciomer Susanna,Palermo Pietro,Contini Mauro,Pezzuto Beatrice,Farina Stefania,Magini Alessandra,De Martino Fabiana,Magrì Damiano,Paolillo Stefania,Cattadori Gaia,Vignati Carlo,Mapelli Massimo,Apostolo Anna,Salvioni Elisabetta

Abstract

In chronic heart failure, minute ventilation (VE) for a given carbon dioxide production (VCO2) might be abnormally high during exercise due to increased dead space ventilation, lung stiffness, chemo- and metaboreflex sensitivity, early metabolic acidosis and abnormal pulmonary haemodynamics. The VEversus VCO2 relationship, analysed either as ratio or as slope, enables us to evaluate the causes and entity of the VE/perfusion mismatch. Moreover, the VE axis intercept, i.e. when VCO2 is extrapolated to 0, embeds information on exercise-induced dead space changes, while the analysis of end-tidal and arterial CO2 pressures provides knowledge about reflex activities. The VEversus VCO2 relationship has a relevant prognostic power either alone or, better, when included within prognostic scores. The VEversus VCO2 slope is reported as an absolute number with a recognised cut-off prognostic value of 35, except for specific diseases such as hypertrophic cardiomyopathy and idiopathic cardiomyopathy, where a lower cut-off has been suggested. However, nowadays, it is more appropriate to report VEversus VCO2 slope as percentage of the predicted value, due to age and gender interferences. Relevant attention is needed in VEversus VCO2 analysis in the presence of heart failure comorbidities. Finally, VEversus VCO2 abnormalities are relevant targets for treatment in heart failure.

Publisher

European Respiratory Society (ERS)

Subject

Pulmonary and Respiratory Medicine

Cited by 8 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3