Incidence of cognitive impairment and dementia after hospitalisation for pneumonia: a UK population-based matched cohort study

Abstract

BackgroundSurvivors of common infections may develop cognitive impairment or dementia, however; the risk of these conditions in people hospitalised with pneumonia is not well-established.MethodsA matched cohort study was conducted using Hospital Episode Statistics (HES) data linked to Clinical Practice Research Database (CPRD). Adults with the first ICD-10 code for pneumonia recorded in HES between 1 July 2002 and 30 June 2017 were included and up to four controls without hospitalisation for pneumonia in CPRD were matched by gender, age, and practice. Cognitive impairment and dementia incidence rates were calculated, and survival analysis was performed comparing those hospitalised with pneumonia to the general population.ResultsThe incidence rates of cognitive impairment and dementia were 18 (95%CI 17.3 to 18.7) and 13.2 (95%CI 13 to 13.5) per 1000 person-years among persons previously hospitalised with pneumonia and the matched cohort respectively. People previously hospitalised with pneumonia had 53% higher incidence of cognitive impairment and dementia (aHR 1.53; 95% CI 1.46 to 1.61) than their matched cohort. The highest incidence was observed within 1-year of hospitalisation for pneumonia compared to the general population (aHR=1.89; 95%CI 1.75 to 2.05). Age modified the effect of hospitalisation for pneumonia on cognitive impairment and dementia such that the size of effect was stronger in people between 45 and 60 years old (pinteraction<0.0001).ConclusionCognitive impairment and dementia are more likely to be diagnosed in people who have been hospitalised for pneumonia, especially in the first year after discharge, than in the general population.