Author:
Vinnikov Denis,Khafagy Abdullah,Blanc Paul D.,Brimkulov Nurlan,Steinmaus Craig
Abstract
We used meta-analysis to measure the effect of high-altitude climate therapy (HACT) on lung function outcomes in asthma, and systematically searched PubMed, Embase andwww.elibrary.rufor publications appearing from 1970 to mid-2015. We included studies carried out with children or adults with an exposure of up to 12 weeks at an altitude of ≥1500 m above sea level. Changes in forced expiratory volume in 1 s (FEV1), FEV1/vital capacity ratio or peak expiratory flow rate as the HACT intervention outcomes were analysed. We included data for 907 participants (age range 4–58 years) from 21 studies, altogether including 28 substrata based on asthma type or severity. Only three of 21 included studies had high quality, whereas 93% of substudies reported lung function improvement with an overall pooled standardised mean difference (SMD) of 0.53 (95% CI 0.43–0.62). The measured effect of HACT was greater in adults (SMD 0.75, 95% CI 0.63–0.88, n=14) than in children (SMD 0.24, 95% CI 0.09–0.38, n=14). Studies at altitude >2000 m above sea level yielded the same effect as those at lower altitude. Based on a cut-point of a 0.50 change in SMD to define a meaningful clinical difference, HACT appears to have efficacy as an intervention. This extent of benefit appears to be limited to adults with asthma.
Publisher
European Respiratory Society (ERS)
Subject
Pulmonary and Respiratory Medicine
Reference44 articles.
1. Global Initiative for Asthma. 2015 Update: Global Strategy for Asthma Management and Prevention. http://ginasthma.org/wp-content/uploads/2016/01/GINA_Report_2015_Aug11-1.pdf Date last accessed: December 10, 2015.
2. Should asthma management include sojourns at high altitude?;Schultze-Werninghaus;Chem Immunol Allergy,2006
3. Altitude and house dust mites
4. High Altitude and House-dust Mites
5. Vliianie vysokogornoi klimatoterapii na funktsiiu kory nad- pochechnikov u bolnykh bronkhial'noi astmoi [Effect of high-altitude climate therapy on the adrenal cortex function in patients with bronchial asthma];Brimkulov;Klin Med (Mosk),1990
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