PREPARATION AND CHARACTERIZATION OF A CipHCl-PLA/PBC/CS COMPOSITE FIBER MEMBRANE FOR ANTIBACTERIAL WOUND DRESSING
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Published:2022-08-16
Issue:4
Volume:56
Page:
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ISSN:1580-3414
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Container-title:Materiali in tehnologije
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language:
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Short-container-title:Mater. Tehnol.
Author:
Gu Xiaohua,Zhang Dasheng,Liu Siwen,Liu Yan
Abstract
In this paper, a polylactic acid (PLA)/polybutylene carbonate (PBC)/chitosan (CS) composite membrane with different mass fractions of ciprofloxacin hydrochloride (CipHCl) drug was prepared through the electrostatic spinning technology. The morphology and chemical structure of the resultant CipHCl-PLA/PBC/CS fiber membranes were characterized with scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). A drug-release test, bacteriostatic test and cytotoxicity test were performed to determine the drug-release properties, bacteriostatic properties and cytotoxicity, respectively. Results show that the CipHCl-PLA/PBC/CS composite fiber membranes have good biocompatibility. When the CipHCl content is 20 w/%, the average fiber diameter is 374 nm. After 192 h, the drug-release rate of the CipHCl-PLA/PBC/CS composite fiber membrane containing 20 w/% of CipHCl reaches 88.2 %. The antibacterial activity of the CipHCl-PLA/PBC/CS composite fiber membrane is much higher than that of the PLA/PBC composite fiber membrane. Besides, the antibacterial activity of the CipHCl-PLA/PBC/CS composite fiber membrane against E. coli is slightly higher than that against S. aureus.
Publisher
Institute of Metals and Technology
Subject
Metals and Alloys,Polymers and Plastics