Chlorination of nucleobases, RNA and DNA by myeloperoxidase: a pathway for cytotoxicity and mutagenesis by activated phagocytes
Author:
Publisher
Informa UK Limited
Subject
Biochemistry (medical),Cell Biology,Clinical Biochemistry,Physiology,Biochemistry
Link
http://www.tandfonline.com/doi/pdf/10.1179/135100099101535025
Reference3 articles.
1. Molecular Chlorine Generated by the Myeloperoxidase-Hydrogen Peroxide-Chloride System of Phagocytes Produces 5-Chlorocytosine in Bacterial RNA
2. Radiation, pool size and incorporation studies in mice with 5-chloro-2′-deoxycytidine
3. Sister-chromatid exchanges and gene mutations are induced by the replication of 5-bromo- and 5-chloro-deoxyuridine substituted DNA
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1. Radiation activates myeloperoxidase (MPO) to generate active chlorine species (ACS) via a dephosphorylation mechanism - inhibitory effect of LGM2605;Biochimica et Biophysica Acta (BBA) - General Subjects;2020-07
2. Synthetic secoisolariciresinol diglucoside (LGM2605) inhibits myeloperoxidase activity in inflammatory cells;Biochimica et Biophysica Acta (BBA) - General Subjects;2018-06
3. Gamma-irradiation produces active chlorine species (ACS) in physiological solutions: Secoisolariciresinol diglucoside (SDG) scavenges ACS - A novel mechanism of DNA radioprotection;Biochimica et Biophysica Acta (BBA) - General Subjects;2016-09
4. Plasma myeloperoxidase levels correlate with hepatocellular carcinoma in chronic hepatitis C;Human Immunology;2012-11
5. DNA damage by reactive species: Mechanisms, mutation and repair;Journal of Biosciences;2012-06-26
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