Hemostasis and Cognitive Brain: 5P-Medicine and Chronotherapy of Arterial Hypertension

Abstract

Neurophysiological and cardioneurological polyfunctional studies of the brain-heart system in the rehabilitation of neurological patients using high medical technologies will help answer many questions related to the optimization of patient management in combined cerebral and cardiac pathology in the recovery period. Late chronotype and later sleep patterns are associated with greater morbidity, including higher rates of metabolic dysfunction and cardiovascular disease (CVD). Numerous studies have been adjusted for age, sex, ethnicity, smoking, body mass index, sleep duration, socioeconomic status, and comorbidities. Age groups, especially being a defined evening type, were significantly associated with a higher prevalence of all comorbidities. The results suggest increased mortality in evening types and increased levels of cardiometabolic risk factors in these groups. The risk of mortality in evening types may be due to behavioral, psychological, and physiological risk factors, many of which may be associated with chronic inconsistencies between internal physiological timelines and external working and social activities. Multilevel and interneural interactions are a leading factor in the formation of higher mental functions and self-development of the personality. Circadian homeostasis regulates and synchronizes the functions of adult stem cells and their changes during aging, as well as modulates their external and internal mechanisms. The circadian clock synchronizes cellular physiology with daily environmental changes and can both positively and negatively affect physiological processes. Circadian onset of CVD often shows a change in the time of day and is associated with the molecular clock system. Acute myocardial infarction or ventricular arrhythmia (ventricular tachycardia) occurs mainly early in the morning. Numerous biochemical and physiological parameters show a circadian rhythm that may explain daily variations in cardiovascular events. These include fluctuations in blood pressure, autonomic nervous system and renin-angiotensin axis activity, blood clotting cascade, vascular tone and intracellular metabolism of cardiomyocytes. New insights into the molecular and cellular pathways by which cardiovascular events occur in a daily oscillatory pattern will help create a new therapeutic approach to CVD treatment. Research continues on the updated modern problem of circadian brain and heart neurocommunications during the period of electromagnetic and information load/overload, the influence of new genetics and epigenetics, changes in hemostasis and homeostasis, the formation of new immunity and microbiota, in conjunction with modern neurobite and neuromarketing, with 5P Medicine and 5G technologies of neurocommunication.