The Effect of Radiation on Hemocoagulation in Animals Under Various Experimental Conditions

Abstract

The effect of the epiphysis and sensory systems on hemocoagulation was studied. Due to the inhibition and activation of the functions of the epiphysis, the neurohormonal regulation of physiological functions changes significantly. Hypercoagulation is observed in epiphysectomized animals. Olfactory bulbectomy accelerates the process of hemocoagulation. Various experimental conditions accelerate the process of hemocoagulation. The main hormone of the epiphysis — melatonin — is a metabolite of serotonin. Under the influence of a specific enzyme hydroxyindole-0-methyltransferase (GIOMT), melatonin is synthesized from serotonin. During the day, under the influence of the light factor, GIOMT is inhibited 10 times and melatonin is almost not synthesized. At night, with a decrease in light information, the activation of GIOMT occurs 10 times. So, by alternating the inhibition and activation of melatonin of the educational function of the epiphysis, the inhibition and activation of the formation of tropic releasing factors of the nuclei of the hypothalamus and tropic hormone formation in the pituitary gland alternates. This process plays a crucial role in the circadian rhythm of physiological processes. In natural conditions, organisms are exposed to sunlight, cosmic rays, and ionizing radiation of terrestrial origin. Ionizing radiation is used in experimental conditions. The biological effect of ionizing radiation depends on the dose, type, energy of radiation and the physiological state of the body.