Study the Role and Value of Antibodies to Cyclic Citrullinated Peptide in Early Rheumatoid Arthritis

Abstract

Research relevance: prognosis of early rheumatoid arthritis (RA) course remains an unresolved problem, which dictates the need to identify new factors affecting the activity and course of the disease. Research objectives: it is assumed that the cause of immunopathological reactions in early RA is a dysregulation of the immune response resulting from an imbalance in the function of T- and B-lymphocytes, namely, the immunodeficiency of the T-lymphocyte system, which leads to uncontrolled synthesis of immunoglobulins by B-lymphocytes, in particular, organo- and tissue-specific antibodies. Research methods: this article analyzes occurrence frequency, pathogenetic and clinical significance of antibodies to cyclic citrullinated peptide (ACCP) in early rheumatoid arthritis (RA). Research results: in this work, in patients with early RA, the detection rate of ACCP was 68.8%, the frequency of detection of ACCP was higher than that of rheumatoid factor. Conclusions: in the examined patients with early RA, the presence of ACCP did not depend on gender and age but depended on the duration of the disease.