Morphofunctional Characteristic of Rat Pancreas in Experimental Hyperglycemia Using Food Sugar

Abstract

Experimental modeling of diabetes mellitus, caused by exposure to alloxan, streptozotocin, dithizone in various dosages and the frequency of administration, is not entirely equivalent in etiopathogenetic mechanisms to the development of this pathology in humans. Of great interest are diet-induced modeling of the pathological process. One of the most important and affordable glucose donors is food sugar (sucrose). In order to study the development of diabetes mellitus in rats with food sugar, 2 groups of animals were formed: control (standard food) and experimental (food sugar), which were taken blood for biochemical studies after 2 weeks, and a month later histological preparations of the pancreas were selected. With the systematic intake of excessive amounts of edible sugar, after 2 weeks there was an increase in blood glucose by 25%, while at the same time, cholesterol increased by 3 times. After a month of research, carbohydrate degeneration of the pancreas is observed, combined with vacuole organ dystrophy and the development of foci of necrosis and sclerosis. Feeding rats for a month with food sugar can serve as an experimental model of carbohydrate pancreatic dystrophy.