Circulating levels of Bcl-2 and its expression in the nasal mucosa of patients with chronic rhinosinusitis-Reference-Cited by-同舟云学术

Circulating levels of Bcl-2 and its expression in the nasal mucosa of patients with chronic rhinosinusitis

Published:2022-12-30 Issue:6 Volume:19 Page:63-67
ISSN:1812-2892
Container-title:Journal of Clinical Medicine of Kazakhstan
language:
Short-container-title:J CLIN MED KAZ

Author:

Kalashnyk-Vakulenko Iuliia¹^ORCID,Gubina-Vakulyck Galina²^ORCID,Onishchenko Anatolii³^ORCID,Nakonechna Oksana⁴,Gorbach Tatyana⁴,Tkachenko Viktoriya⁵,Tkachenko Anton³^ORCID

Affiliation:

1. Department of Otorhinolaryngology, Kharkiv National Medical University, Kharkiv, Ukraine

2. Department of Pathological Anatomy, Kharkiv National Medical University, Kharkiv, Ukraine

3. Research Institute of Experimental and Clinical Medicine, Kharkiv National Medical University, Kharkiv, Ukraine

4. Department of Biochemistry, Kharkiv National Medical University, Kharkiv, Ukraine

5. Department of Microbiology, Virology and Immunology, Kharkiv National Medical University, Kharkiv, Ukraine

Abstract

Aim: To evaluate expression of anti-apoptotic Bcl-2 protein in the nasal tissue and its levels in blood serum of patients with chronic rhinosinusitis with (CRSwNP) and without nasal polyps (CRSsNP). Material and methods: Expression of Bcl-2 in the sinonasal tissue and its levels in blood serum of patients with CRSsNP and CRSwNP were evaluated immunohistochemically and using ELISA, respectively. Results: In patients with CRSsNP, Bcl-2 was overexpressed in nasal epithelial cells mainly in the atrophic regions. However, its upregulation was also observed in regions with epithelial cell proliferation. Immunostaining for Bcl-2 was stronger both in the stroma and epithelial lining compared with control subjects. The level of Bcl-2 in blood serum was elevated in both forms of chronic rhinosinusitis with a more pronounced increase in CRSwNP. Conclusion: CRSsNP and especially CRSwNP are associated with overexpression of anti-apoptotic Bcl-2 in nasal epithelial and cells in the lamina propria against the background of elevated circulating concentrations of Bcl-2.

Publisher

JSC National Scientific Medical Research Center

Subject

General Medicine

Link

https://www.clinmedkaz.org/download/circulating-levels-of-bcl-2-and-its-expression-in-the-nasal-mucosa-of-patients-with-chronic-12689.pdf

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