The association between non-HDL cholesterol and SYNTAX score in premature heart disease

Abstract

<b>Aim: </b>This study aimed to estimate the association of coronary artery disease complexity with non-HDL-C levels in premature CAD.<br /> <b>Background: </b>Primary prevention has utmost importance in terms of minimizing the number of patients who had premature coronary artery disease (CAD). Non-high density lipoprotein cholesterol (non-HDL-C) contains potentially atherogenic lipoprotein fractions.<br /> <b>Material and methods</b>: Coronary angiographic recordings of two hundred acute coronary syndrome patients were evaluated by two cardiologists. Clinical, demographic and lipid parameters of the patients were compared with SYNTAX score.<br /> <b>Results</b>: Median age of the study group was 41 (18-45) years. One hundred eighty five (90.5%) of them were male, nineteen (9.5%) of them were female. Median SYNTAX score and ejection fraction of the patients were 17 (4.5-39) and 50 (33-68), respectively. SYNTAX score of the male patients was significantly higher compared to females [17 (4.5-39) vs 12 (8-26), p=0.048), similarly, diabetic patients had higher values of syntax score compared to non-diabetic patients [19 (10-39) vs 16 (4.5-37), p=0.005), There were no differences of SYNTAX score with respect to presence of hypertension, smoking status and family history of CAD. &nbsp;There were very strong positive correlation between SYNTAX score and non-HDL-C, TC and LDL-C levels (r=0.958, r=0.946 and r=0.921, respectively, p&lt;0.001 for all).&nbsp;&nbsp; HgA1c levels showed positive correlation, whereas HDL-C showed negative correlation with SYNTAX score (r=0.793 and r=-0.620, respectively, p&lt;0.001 for both).<br /> <b>Conclusion</b>: non-HDL-C was a valuable tool in assessing the complexity of atherosclerotic cardiovascular disease in young patients.