Importance of Organophosphorus Compounds in Medicinal Chemistry Field

Abstract

Organophosphorus chemistry has a crucial role in the field of drug research [1]. As generally well known, the Adenosine Triphosphate (ATP) plays a key role in the energy processes in all living cells of mammals. There are also natural phosphorus containing organic compound, Phosphocitrate (PC), found in mammalian mitochondria, likely produced by cytosolic phosphorylation of citrate, and which has important role in calcium metabolism, e.g. inhibiting hydroxyapatite precipitation in cells [2-4].