Author:
Pakhrin Sonu,Shrestha Sumitra,Karki Renu,Marasine Nirmal Raj,Lama Rajendra,Pokhrel Mandip
Abstract
Background: Drug dosage adjustment is essential for chronic kidney disease patients (CKD) patients. If it is not done properly, this will lead to an increase in toxicity and a decrease in the effectiveness of therapy. The objective of the present study was to assess whether appropriate dosage adjustments were made in hospitalized CKD patients.
Methods: A descriptive cross-sectional study was carried out among 80 CKD patients with stage II to V admitted in the nephrology ward of Chitwan Medical College Teaching Hospital, Nepal between 1st August to 30th November 2018. All patients with renal clearance ≤90 ml/min/1.73 m2 were included for the analysis. Data concerning patient’s clinical, medications and dosages, laboratory findings were extracted from the medical record section.
Results: Total of 81 numbers of prescribed drugs was found in eighty hospitalized CKD patients. Twenty-seven were found requiring dose adjustment. Dose adjustment according to renal function was judged as necessary in 27 dose adjustment required drugs. Among these, 11 (40.7% of 27) drugs were considered appropriate in dosing, whereas 16 (59.3%) were found to be inappropriate. A total of 13 (81.3%) number of drugs were inappropriately adjusted in stage V patients.
Conclusion: Dosing errors were the most frequently observed challenge in the patient hospitalized with CKD. This study also intensified the need for strong monitoring of drug therapy which will bear in achieving the better therapeutic outcomes that improve the quality of life and decrease the various problems associated with dosing error.
Publisher
Nirvana Psychosocial Care Center and Research Institute
Reference34 articles.
1. Neuen BL, Chadban SJ, Demaio AR, Johnson DW, Perkovic V. Chronic kidney disease and the global NCDs agenda. BMJ Global Health. 2017;2(2):e000380. https://doi.org/10.1136/bmjgh-2017-000380 [Pubmed]
2. Nwose EU, Obianke J, Richards RS, Bwitit PT, Igumbor EO. Prevalence and correlations of hepatorenal functions in diabetes and cardiovascular disease among stratified adults. Acta Biomed. 2019;90(1):97-103. [Pubmed | Full Text | DOI]
3. Chapter 1: Definition and classification of CKD. Kidney Int Suppl (2011). 2013;3(1):19-62. https://doi.org/10.1038/kisup.2012.64 [Pubmed | Full Text ]
4. Levey AS, Becker C, Inker LA. Glomerular filtration rate and albuminuria for detection and staging of acute and chronic kidney disease in adults: a systematic review. JAMA. 2015;313(8):837-846. https://doi.org/10.1001/jama.2015.0602 [Pubmed | Full Text]
5. Ang HG, Pua YH, Subari NA. Mandatory continuing professional education in pharmacy: the Singapore experience. International journal of clinical pharmacy. Aug 2013;35(4):570-576. https://doi.org/10.1007/s11096-013-9767-y [Pubmed | Full Text]
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献