Morphological characteristics of toxic brain damage-Reference-Cited by-同舟云学术

Morphological characteristics of toxic brain damage

Published:2024-06 Issue:2024(2) Volume: Page:
ISSN:
Container-title:Medicine of Extreme Situations
language:ru
Short-container-title:MES

Author:

Gaykova ON¹,Kozlov AA¹,Katretskaya GG¹,Melnikova MV¹,Melekhova AS¹,Bondarenko AA¹,Sokolova YuO¹,Bazhanova ED²

Affiliation:

1. Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency, Saint-Petersburg, Russia

2. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint-Petersburg, Russia

Abstract

The effects of various toxicants on the body tissues cause tissue abnormalities resulting in dystrophic changes and necrosis. The nervous system is the most vulnerable to the effects of exogenic substances, both chemical and biological, due to high metabolic activity and the cells' incapability of self-renewal. Neurotoxicants lead to disturbances of cellular nutrition and eventually to neurodegeneration. Neurons can die due to both apoptosis and necrosis.

Publisher

Federal Medical Biological Agency

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