IAEA Activities on 67Cu, 186Re, 47Sc Theranostic Radionuclides and Radiopharmaceuticals-Reference-Cited by-同舟云学术

IAEA Activities on 67Cu, 186Re, 47Sc Theranostic Radionuclides and Radiopharmaceuticals

Published:2021-11-10 Issue:4 Volume:14 Page:306-314
ISSN:1874-4710
Container-title:Current Radiopharmaceuticals
language:en
Short-container-title:CRP

Author:

Jalilian Amir R.¹,Gizawy Mohamed A.²,Alliot Cyrille³,Takacs Sandor⁴,Chakarborty Sudipta⁵,Rovais Mohammad R.A.⁶,Pupillo Gaia⁷,Nagatsu Kotaro⁸,Park Jeong H.⁹,Khandaker Mayeen Uddin¹⁰,Mikolajczak Renata¹¹,Bilewicz Aleksander¹²,Okarvi Subhani¹³,Gagnon Katherine¹⁴,Al Rayyes Abdul H.¹⁵,Lapi Suzanne E.¹⁶,Starovoitova Valeriia¹,Korde Aruna¹,Osso Joao A.¹

Affiliation:

1. Department of Nuclear Sciences and Applications, International Atomic Energy Agency (IAEA), Vienna International Centre, PO Box 100, 1400, Vienna, Austria

2. Radioisotopes Production Facility (RPF), Second Research Reactor (ETRR-2) and Labeled Compounds Department, Hot Labs Center, Egyptian Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

3. CRCINA, 8 quai Moncousu, 44007 Nantes cedex 1, France & GIP Arronax, 1 rue Aronnax, 44817 Saint-Herblain cedex, France & GIP ARRONAX, rue Aronnax, CS 10112 - 44817 SAINT-HERBLAIN Cedex, France

4. Institute for Nuclear Research, Bem ter 18/c, 4026Debrecen, Hungary

5. Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai -4000, 085, India

6. Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), P.O. Box 14395-836, Tehran, Iran

7. Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro (INFN-LNL), Viale dell'Università 2, 35020 Legnaro (PD), Italy

8. Dept. of Radiopharmaceuticals Development, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage, 263-8555Chiba, Japan

9. Korea Atomic Energy Research Institute, Jeongeup, Jeonbuk 56212, Korea

10. Department of Physics, University of Malaya, 50603 Kuala Lumpur, Malaysia & Center for Biomedical Physics, Sunway University, 47500 Bandar Sunway, Selangor, Malaysia

11. Radioisotope Centre POLATOM, National Centre for Nuclear Research, Andrzej Soltan 7, 05-400, Otwock, Poland

12. Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195Warsaw, Poland

13. Cyclotron and Radiopharmaceuticals Department. King Faisal Specialist Hospital and Research Centre, Takhasussi Road, P.O. Box 3354, 11211Riyadh, Saudi Arabia

14. Cyclotrons and TRACERcenter, GEMS PET Systems AB, GE Healthcare, Uppsala, Sweden

15. Department of Radioisotope, Atomic Energy Commission of Syria (AECS), P.O. Box 6091, Damascus, Syrian Arab Republic

16. Cyclotron Facility, Division of Advanced Medical Imaging Research, Department of Radiology and Chemistry, University of Alabama at Birmingham, Wallace Tumor Institute 310F, 1824 6th Ave. South, Birmingham, AL35233-3300, United States

Abstract

Despite interesting properties, the use of 67Cu, 186Re and 47Sc theranostic radionuclides in preclinical studies and clinical trials is curtailed by their limited availability due to a lack of widely established production methods. An IAEA Coordinated Research Project (CRP) was initiated to identify important technical issues related to the production and quality control of these emerging radionuclides and related radiopharmaceuticals, based on the request from IAEA Member States. The international team worked on targetry, separation, quality control and radiopharmaceutical aspects of the radionuclides obtained from research reactors and cyclotrons leading to preparation of a standard recommendations for all Member States. The CRP was initiated in 2016 with fourteen participants from thirteen Member States from four continents. Extraordinary results on the production, quality control and preclinical evaluation of selected radionuclides were reported in this project that was finalized in 2020. The outcomes, outputs and results of this project achieved by participating Member States are described in this minireview.

Funder

Nuclear R&D Program, National Research Foundation

The Polish Ministry of Science and Higher Education

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Radiology, Nuclear Medicine and imaging

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