Pre-feasibility Study for Establishing Radioisotope and Radiopharmaceutical Production Facilities in Developing Countries

Author:

Perini Efrain Araujo1,Skopchenko Mikhail2,Hong Tran Thu3,Harianto Rahmat4,Maître Alexis5,Rodríguez Maidelys Rosa Rodríguez6,de Oliveira Santos Nathalia7,Guo Yinglei8,Qin Xiangyu9,Zeituni Carlos A.1,Starovoitova Valeriia N.10

Affiliation:

1. Institute of Energy and Nuclear Research (IPEN), Av. Prof. Lineu Prestes 2242, Cidade Universitaria., 05508-000, Sao Paulo, SP, Brazil

2. National Nuclear Center, Institute of Radiation Safety and Ecology, 23 Building, 2 Krasnoarmeyskaya Street, 071100, Kurchatov, Kazakhstan

3. Nuclear Research Institute, 01 Nguyen Tu Luc St., Ward 9, Dalat City, Lam Dong, Vietnam

4. Nuclear Energy Regulatory Agency (BAPETEN), North Petojo, Jl. Gajah Mada 8, RT.1/RW.2, Krukut, Tamansari, Daerah Khusus Ibukota 11120, Jakarta, Indonesia

5. INVAP S.E., Avenida Comandante Luis Piedrabuena 4950, R8403CPV, Bariloche, Argentina

6. National Centre for Nuclear Safety. Street 28, building 504, Miramar, Playa, La Habana, Cuba

7. Eckert & Ziegler Brasil Isotope Solution, Rua Miguel Nelsom Bechara, 480, Jardim Pereira Leite, ZIP 02712-130, Sao Paulo - SP, Brazil

8. GAOTONG Isotope Co. Ltd., Chengdu, China

9. CIRCHTA Ltd., Beijing, China

10. Niowave Inc, 1012 N Walnut St, Lansing, 48906, MI, United States

Abstract

Background:A significant number of developing countries have no facilities to produce medical radioisotopes and radiopharmaceuticals.Objective:In this paper we show that access to life-saving radioisotopes and radiopharmaceuticals and the geographical distribution of corresponding infrastructure is highly unbalanced worldwide.Methods:We discuss the main issues which need to be addressed in order to establish the production of radioisotopes and radiopharmaceuticals, which are especially important for developing countries as newcomers in the field. The data was gathered from several sources, including databases maintained by the International Atomic Energy Agency (IAEA), World Health Organization (WHO), and other international organizations; personal interactions with representatives in the nuclear medicine field from different regions of the world; and relevant literature.Results:Developing radioisotope and radiopharmaceutical production program and installing corresponding infrastructure requires significant investments, both man-power and financial. Support already exists to help developing countries establish their medical radioisotope production installations from several organizations, such as IAEA.Conclusion:This work clearly shows that access to life-saving radioisotopes and the geographical distribution of corresponding infrastructure is highly unbalanced. Technology transfer is important as it not only immediately benefits patients, but also provides employment, economic activity and general prosperity in the region to where the technology transfer is implemented.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Radiology Nuclear Medicine and imaging

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