Affiliation:
1. Department of Pharmaceutical Chemistry, Arvind Gavali College of Pharmacy, Satara, 415004, India
2. Department of
Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, 416406, India
3. Department of Pharmaceutics,
Rajarambapu College of Pharmacy, Kasegaon, 416406, India
Abstract
Background:
Silent onset and metastasis in tissues make cancer the most devastating
illness globally. Monitoring the growth of the tumour and delivering drugs to specific tissues are
some of the major issues associated with treatment. However, with an improved understanding of
tumour microenvironments and advancements in nanocarriers of drugs, novel nano-targeting pathways
that can be utilised by nanocarriers have been developed. Carbon Dots, with their tiny size and
outstanding physicochemical features, are an emerging category of carbon nanostructures that have
attracted a lot of curiosity.
Objective:
Multitudinous attempts and extensive studies have been undertaken by many researchers
regarding the synthesis of Carbon Dots and their applications in various fields. These studies have
explained that the synthesised Carbon Dots have versatile surface functionalities, high luminescence,
and excellent biocompatibility. This article focuses on recent developments in synthesis approaches,
carbon precursors used, and applications of Carbon Dots, specifically within the biomedical field,
with a particular focus on cancer.
Results:
Carbon dots synthesised from a variety of precursors can act as prominent candidates for
bioimaging and drug carriers and are used in cancer phototherapy. In this article, Carbon Dots are
summarised based on their bright luminescent properties, distinct structure, drug loading capacity,
and near-infrared (NIR) emission.
Conclusion:
Carbon dots, employed as tumour theranostics, can serve as an alternative to synthetic
fluorescent dyes. They fulfil the role of bioimaging agents and facilitate the precise delivery of drugs
to cancer cells. Additionally, they exhibit excellence as phototherapeutic agents, featuring high nearinfrared
(NIR) emission and minimal side effects.
Publisher
Bentham Science Publishers Ltd.
Cited by
1 articles.
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