A Review on Thiocyanation of Indoles-Reference-Cited by-同舟云学术

A Review on Thiocyanation of Indoles

Published:2021-05 Issue:3 Volume:18 Page:233-247
ISSN:1570-1794
Container-title:Current Organic Synthesis
language:en
Short-container-title:COS

Author:

Divyavani Chitteti¹,Padmaja Pannala²,Ugale Vinod G.³,Reddy Pedavenkatagari Narayana⁴

Affiliation:

1. Department of Chemistry, Sri Padmavathi Women’s Degree & PG College, Tirupati, Andhra Pradesh,India

2. Fluoro & Agrochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad,India

3. Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur- 425405, Maharashtra,India

4. Department of Chemistry, School of Science, Gitam Deemed to be University, Telangana,India

Abstract

Background: The thiocyanation of indoles is a direct way for carbon-sulfur bond formation to access 3-thiocyanato-indoles. 3-thiocyanato-indoles exhibit potent biological and pharmacological activities and also serve as building blocks to synthesize many biologically active sulfur-containing indole derivatives. Objective: The aim of this review is to highlight different approaches for the thiocyanation of indoles focusing on its scope and mechanism. Conclusion: In this review, we have summarized various methods for the thiocyanation of indoles. Selection of new methods for the preparation of 3-thiocyanato-indoles will be done. The mechanistic aspects and significance of the methods are also briefly discussed.

Funder

Department of Science and Technology

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry,Biochemistry

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