Facile Synthetic Protocols for the Preparation of New Impurities in Pemetrexed Disodium Heptahydrate as an Anti-cancer Drug-Reference-Cited by-同舟云学术

Facile Synthetic Protocols for the Preparation of New Impurities in Pemetrexed Disodium Heptahydrate as an Anti-cancer Drug

Published:2022-02 Issue:1 Volume:19 Page:2-9
ISSN:1570-1794
Container-title:Current Organic Synthesis
language:en
Short-container-title:COS

Author:

Jaggavarapu Rama Mohana Reddy¹,Muvvala Venkatanarayana²,Ghojala Venkatareddy³,Babu H. Sharath²,Cheedarala Ravi Kumar⁴

Affiliation:

1. Department of Chemistry, Gitam School of Science, GITAM (Deemed to be University), Hyderabad, Telangana, 502329, India | MSN Laboratories Pvt. Ltd. Sy. No. 50, Kardanur (V), Patancheru(M), Sangareddy Dist., Telangana State, India

2. Department of Chemistry, Gitam School of Science, GITAM (Deemed to be University), Hyderabad, Telangana, 502329, India

3. MSN Laboratories Pvt. Ltd. Sy. No. 50, Kardanur (V), Patancheru(M), Sangareddy Dist., Telangana State, India

4. Department of Chemistry, Pohang University of Science and Technology (POSTECH), San 31 Hyojadong, Pohang, Kyeongbuk, 790-784, Republic of Korea

Abstract

Abstract: A facile synthetic protocol was employed to prepare process-related impurities associated with the synthesis of pemetrexed disodium heptahydrate, Alimta. The research work is described for the development of the novel synthetic methods and their structure elucidation of Pemetrexed glutamide, N-methyl pemetrexed, and N-methyl pemetrexed glutamide impurities. The listed impurities were deduced through spectral analysis, such as 1H-NMR, 13CNMR, and HRMS. The target compounds can be used as the reference substances for quality control.

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry,Biochemistry