Affiliation:
1. Department of Organic Chemistry, Chemistry Institute, Federal Rural University of Rio de Janeiro, Seropedica, Brazil
2. Farmanguinhos, Fundacao Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil
Abstract
Multicomponent reactions (MCRs) are composed of three or more reagents in which the final
product has all or most of the carbon atoms from its starting materials. These reactions represent, in the
medicinal chemistry context, great potential in the research for new bioactive compounds, since their products
can present great structural complexity. The aim of this review is to present the main multicomponent reactions
since the original report by Strecker in 1850 from nowadays, covering their evolution, highlighting their
significance in the discovery of new bioactive compounds. The use of MCRs is, indeed, a growing field of
interest in the synthesis of bioactive compounds and approved drugs, with several examples of commerciallyavailable
drugs that are (or can be) obtained through these protocols.
Funder
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry