Recent Updates on Synthesis, Biological Activity, and Structure-activity Relationship of 1,3,4-Oxadiazole-quinoline Hybrids: A Review

Author:

Salahuddin 1ORCID,Sharma Abhishek Shankar1ORCID,Mazumder Avijit1ORCID,Kumar Rajnish1ORCID,Datt Vimal1ORCID,Shabana Km1ORCID,Tyagi Sonakshi1ORCID,Yar Mohammad Shahar2ORCID,Ahsan Mohamed Jawed3ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), 19, Knowledge Park II, Greater Noida, U.P. - 201306, India

2. Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard University, Hamdard Nagar, New Delhi-110062, India

3. Department of Pharmaceutical Chemistry, Maharishi Arvind College of Pharmacy, Ambabari Circle, Jaipur, Rajasthan- 302039, India

Abstract

Abstract: Due to their diverse applications in industrial and synthetic organic chemistry, quinoline and 1,3,4-oxadiazole have become important heterocyclic compounds. Quinoline and 1,3,4- oxadiazole compounds have been developed for various medical conditions such as anti-cancer, anti-bacterial, anti-fungal, antimalarial, antioxidants, anti-HIV, anticonvulsant, antiviral, etc. The current review includes synthetic protocols for biologically active 1,3,4-oxadiazole incorporating quinoline hybrids with their structure-activity relationship to explore work (Mainly from 2010 to 2021) based on 1,3,4-oxadiazole-quinoline hybrids to the medicinal chemist for further research in the development of the molecule.

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry,Biochemistry

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