Affiliation:
1. Department of Pharmaceutical Sciences, School of Pharmacy, Lovely Professional University, Punjab, 144001, India
Abstract
Abstract:
Cancer is the second most source of cessation of life globally, with 9.6 million expirations
at each stage around the globe. The resistance to the current chemotherapies urges researchers
to develop new drugs to be available in the market. Among the wide range of drugs synthesized,
heterocyclic compounds play a major role due to the abundance of heterocyclic rings in
biological substances. In medicinal chemistry, benzimidazole is an important pharmacophore and
a privileged structure. This bicyclic compound is made up of the fusion of a six-membered benzene
ring and a five-membered imidazole ring with two nitrogen atoms at 1,3-positions. The
benzimidazole ring has a great deal of stability. Many strong acids and alkalis do not affect benzimidazoles.
The benzene ring of benzimidazole cleaves only under extreme conditions. Except
in certain circumstances, the benzimidazole ring is also quite resistant to reduction. It is the most
popular nucleus to study because of its wide range of biological functions. The recently developed
methods for preparing benzimidazoles, such as condensation of o-phenylene diamines (OPDs)
with aldehydes and many others using a wide range of nano, metal-based catalysts under solventfree
conditions, are discussed in detail in the current studies.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry
Cited by
4 articles.
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