A one-pot synthesis of 2,3-disubstituted-4(3H)-quinazolinone from o-aminobenzoic acid and DMF derivatives using imidazole hydrochloride as a promoter
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Published:2023-08-15
Issue:
Volume:21
Page:
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ISSN:1570-1794
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Container-title:Current Organic Synthesis
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language:en
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Short-container-title:COS
Author:
Yuan Jianyong1,
Wang Yin1,
Zhang Xiuyu2,
Li Suzhen1,
Guo Mengyi1,
Ma Wanqian1
Affiliation:
1. Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, PR China
2. Department of Pharmacy, The People’s Hospital of Kaizhou District, Chongqing
Abstract
Abstract:
As a novel and environmentally friendly Brönsted acid, imidazole hydrochloride was used to promote the synthesis of 2,3-disubstituted-4(3H)-quinazolinone from o-aminobenzoic acid and DMF derivatives. The essence of this reaction is a multicomponent reaction, which constructs multiple chemical bonds between different components through the transamidation of imidazole hydrochloride. This protocol showed a wide range of functional group tolerance, and a series of quinazolinones were synthesized in low to moderate yields without metal catalysts, oxidants or other additives.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry