Affiliation:
1. Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt
2. Department of Chemistry, Faculty of Science, Aswan University, 81528 Aswan, Egypt
Abstract
Pyrazolo-oxazine fused systems are interesting classes of heterocyclic compounds
exhibiting pronounced biological applications such as anticancer, antitubercular,
anti-inflammatory, antibacterial and antifungal activities as well as inhibiting COX-1 and
COX-2 enzymes. Depending on the distribution position of the heteroatoms (N and O), there
are fourteen different systems of pyrazolo-oxazine. Nine of them were biologically abundant
in literature, for example, pyrazolo[3,4-e][1,3]oxazines are used as analogs of antibiotics
Formycin, Formycin B, Oxoformycin B. This review article summarizes the concerted efforts
expended on most of the synthetic routes to the various types of pyrazolo-oxazines in
the literature until the first quarter of 2020. The reactions of pyrazolo-oxazines with various
reagents are also outlined.
Publisher
Bentham Science Publishers Ltd.
Cited by
7 articles.
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