Affiliation:
1. Department of Chemistry, Government College University Faisalabad, 38000-Faisalabad, Pakistan
2. Department of Chemistry, University
of Engineering and Technology Lahore, Faisalabad Campus, 38000-Faisalabad, Pakistan
Abstract
Background:
Betti bases are pharmaceutically and synthetically important scaffolds due to their diverse
range of biological activities and applications in key synthetic transformations in organic synthesis.
Objective:
This work has been sought to contribute to the development, design, and implementation of an improved
green methodology with higher atom economy and lower E-factor values for the synthesis of Betti bases.
Method:
To realize our objectives, we screened out different catalysts and reaction conditions using one-pot multicomponent
modified Mannich reaction/Betti reaction by employing 2-naphthol, benzaldehyde and pyrrolidine as
model substrates.
Results:
The developed methodology afforded functionalized Betti bases in 60-100% yields via FeCl3•6H2O catalyzed
one-pot multi-component Betti reaction under neat conditions at 110 °C (5-15 min) using several aromatic aldehydes
and secondary amines.
Conclusion:
A facile synthetic methodology with higher atom economy and lower E-factor values to synthesize Betti
bases via FeCl3•6H2O catalyzed one-pot multicomponent Betti reaction of 2-naphthol, aromatic aldehydes, and secondary
amines under neat conditions at 110 °C has been reported. The developed methodology offers various advantages,
such as excellent yields (60-100%), short reaction time (5-15 min), wide substrate scope (12 examples),
green reaction conditions, use of readily available catalyst, and easy purification (without column chromatography).
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry
Cited by
5 articles.
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