Affiliation:
1. Department of Molecular Biology, Palladin Institute of Biochemistry, Kyiv,Ukraine
Abstract
Background:
Endoplasmic reticulum to nucleus signaling 1 (ERN1) is a major signaling
pathway of endoplasmic reticulum stress and is crucial for malignant tumor growth.
Objective:
The article aims to discuss the recent progress in the discovery of endoplasmic reticulum
stress targets and their involvement in tumor growth.
Methods:
Literature from the PubMed database related to the endoplasmic reticulum stress involvement
in the tumor growth and chemoresistance was searched and reviewed.
Results:
The endoplasmic reticulum stress plays an important part in malignant tumor growth and
is involved in invasion and metastasis. Inhibition of protein kinase and endoribonuclease activities
of the ERN1 signaling protein significantly reduces tumor growth through down-regulation of angiogenesis
and cell proliferation but activates the invasion. ERN1 knockdown affects the expression
of many genes associated with the regulation of apoptosis, cell proliferation, and survival as
well as reprograms the hypoxic regulation of most gene expressions. Simultaneously, inhibition of
ERN1 endoribonuclease only has a stronger suppressive effect on tumor growth and decreases the
invasiveness.
Conclusion:
Present review summarizes the recent advances in inhibiting ERN1 signaling that regulates
tumor growth. Further understanding of the regulatory mechanisms of genome reprogramming
upon inhibition of ERN1 signaling may help discover new possibilities for developing novel
effective therapeutics.
Publisher
Bentham Science Publishers Ltd.
Subject
Cancer Research,General Pharmacology, Toxicology and Pharmaceutics,Oncology
Cited by
3 articles.
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