Affiliation:
1. Integrative Biochemistry & Immunology Laboratory, Department of Animal Science, Kazi Nazrul University, Asansol-713 340, West Bengal,India
Abstract
Mechanism of cardiac injury in COVID-19 is a serious problem and
plays critical role in mediating the severity of the disease. However, the mechanistic
insights of the induction of the inflammatory signal leading to cardiac injury
was poorly understood. However, few recent studies have indicated the involvement
of Toll-Like Receptors (TLRs) as the major ‘culprit’ behind eliciting
the initial signal of ‘cytokine storm’. As a result, TLRs are now considered as the
therapeutic targets to develop efficacious therapeutics. Herein, we present an
overall summary on the mechanistic insight of cardiac injury in COVID-19 patients
and the therapeutic promises of TLR-targeted therapies.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Infectious Diseases,Drug Discovery
Cited by
4 articles.
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