Affiliation:
1. ISF College of Pharmacy, Moga, 142001, Punjab, India
Abstract
Abstract:
Recently, natural products have been became the center of attraction for the
scientific society and exploration of their biologically abilities is proceeding continuously.
In search for novel antiparasitic agents with an objective of protecting humans from
parasitic infections, the present work was focused on naphthoquinones possessing antiparasitic
activity. Among naphthoquinones, plumbagin is one of the secondary metabolites
exhibiting diverse biological properties such as antibacterial, antimalarial, antiinflammatory,
insecticidal and antiparasitic. Plumbagin is reported to have antischistosomiasis,
anti-haemonchosis, anti-fascioliasis, antiotoacariasis, anti-leishmaniasis,
antimalaria, antiallergic and anthelmintic activities. Besides, various methods of extraction
of plumbagin from different methods, their effectiveness against different parasites,
and the structure-activity relationship reported by different researchers. This work highlight
on recent advancements in the phytochemistry of plumbagin, studies associated
with various biological activities. The structure-activity relationship studies have also
been summarized. To conclude, present review could be beneficial for the scientific
community to get better insight into medicinal research of plumbagin and may provide a
new horizon for the rational design of plumbagin based compounds.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Infectious Diseases,Drug Discovery
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