Affiliation:
1. Hypertension Unit (ESH Excellence Center), Department of Internal Medicine, University Hospital of Heraklion, Heraklion,
Crete, Greece
Abstract
Background:
Impaired fasting glucose (IFG) predisposes to the future development of
type 2 diabetes mellitus (T2DM) and may also be associated with increased cardiovascular disease
(CVD) risk. Hypertension is an established CVD risk factor.
Objective:
This study aimed to assess the prevalence of IFG and the associated anthropometric and
metabolic disturbances in patients with hypertension.
Method:
Consecutive hypertensive patients not on any hypolipidemic treatment and without a diagnosis
of T2DM were included. IFG was defined as serum glucose 100 mg/dl according to the
American Diabetes Association criteria.
Results:
The total sample consisted of 1381 participants; between them, 78 patients were diagnosed
to have T2DM and they were excluded from the analyses, leaving a final sample of 1303 hypertensive
patients [41.0% men; median age 58 (range: 15-90) years] not on any hypolipidemic treatment
and without a diagnosis of T2DM. IFG was identified in 469 patients (36%). IFG was more prevalent
in males than in females (42.4% vs. 31.8%, p<0.001). Patients with IFG had greater body mass
index (BMI), waist-to-hip ratio, systolic blood pressure, pulse pressure, triglycerides, alanine aminotransferase,
gamma-glutamyl transferase, and uric acid serum levels compared with patients with
normal serum glucose levels.
Conclusion:
This study reveals that in a sample of patients with hypertension, one out of three has
IFG. This is more prevalent among men. IFG is associated with the presence of a more aggravated
anthropometric and biochemical profile, possibly associated with an increased CVD risk.
Publisher
Bentham Science Publishers Ltd.
Cited by
1 articles.
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