Ethanol Induced Oxidative Stress in the Vasculature: Friend or Foe

Abstract

Oxidative stress is implicated in the etiology of many ethanol-induced pathologies. Oxidative stress has been shown to contribute to the development of endothelial dysfunction and cardiovascular disease, such as hypertension. This review details mechanisms of vascular function, the role of oxidative stress in vascular biology and how ethanol consumption may alter endothelial and smooth muscle cell function as well as microvascular function. Also reviewed are data from human investigations that have examined the association between alcohol consumption and changes in blood pressure and increased risk for hypertension.