Evaluation of Effect of Triterpenes and Limonoids on Cell Growth, Cell Cycle and Apoptosis in Human Tumor Cell Lines-Reference-Cited by-同舟云学术

Evaluation of Effect of Triterpenes and Limonoids on Cell Growth, Cell Cycle and Apoptosis in Human Tumor Cell Lines

Published:2010-12-01 Issue:10 Volume:10 Page:769-776
ISSN:1871-5206
Container-title:Anti-Cancer Agents in Medicinal Chemistry
language:en
Short-container-title:ACAMC

Author:

M. Cazal Cristiane,Choosang Kantima,Gisele P. Severino Vanessa,S. Soares Marcio,Lucio F. Sarria Andre,B. Fernandes Joao,Fatima G.F. Silva Maria,Cezar Vieira Paulo,Pakkong Pannee,M. Almeida Gabriela,Helena Vasconcelos M.,S.J. Nascimento Maria,M.M. Pinto Madalena¹

Affiliation:

1. CEQUIMED-UP - Centro de Estudos de Quimica Medicinal, Faculdade de Farmacia, Universidade do Porto, Rua Anibal Cunha 164, 4050-047 Porto, Portugal., Portugal

Abstract

Six triterpenes and eight limonoids were evaluated for their capacity to inhibit the growth of three human tumour cell lines, breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). The mechanisms involved in the observed cell growth arrest of the four most potent compounds were carried out by studying their effect in cell cycle profile and programmed cell death. The results showed that one triterpene (odoratol) and two limonoids (gedunin and cedrelone) caused cell cycle arrest while only the limonoids gedunin and cedrelone were found to be very potent inducers of apoptosis.

Publisher

Bentham Science Publishers Ltd.

Subject

Cancer Research,Pharmacology,Molecular Medicine

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