Affiliation:
1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 151 Malianwa North Road, Haidian District, Beijing 100193,China
Abstract
Background:
Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs), small interfering
RNAs (siRNAs) and long noncoding RNAs (lncRNAs), play significant regulatory roles in plant development
and secondary metabolism and are involved in plant response to biotic and abiotic stresses.
They have been intensively studied in model systems and crops for approximately two decades and massive
amount of information have been obtained. However, for medicinal plants, ncRNAs, particularly
their regulatory roles in bioactive compound biosynthesis, are just emerging as a hot research field.
Objective:
This review aims to summarize current knowledge on herbal ncRNAs and their regulatory
roles in bioactive compound production.
Results:
So far, scientists have identified thousands of miRNA candidates from over 50 medicinal
plant species and 11794 lncRNAs from Salvia miltiorrhiza, Panax ginseng, and Digitalis purpurea.
Among them, more than 30 miRNAs and five lncRNAs have been predicted to regulate bioactive
compound production.
Conclusion:
The regulation may achieve through various regulatory modules and pathways, such as
the miR397-LAC module, the miR12112-PPO module, the miR156-SPL module, the miR828-MYB
module, the miR858-MYB module, and other siRNA and lncRNA regulatory pathways. Further functional
analysis of herbal ncRNAs will provide useful information for quality and quantity improvement
of medicinal plants.
Funder
CAMS Innovation Fund for Medical Sciences
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Biotechnology
Cited by
14 articles.
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