Discovering Protein-targeted Antitumor Inhibitors: Drug Screening Strategy and Molecular Mechanisms

Author:

Xu Jianqiang1,Lu Jun2

Affiliation:

1. Dalian University of Technology, Panjin-124221, China

2. Southwest University, Chongqing-400715, China

Abstract

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmaceutical Science,Biotechnology

Reference5 articles.

1. Li L.; Yang M.; Li C.; Xue H.; Shi M.; Liu Y.; Strategy of Virtual Screening Based Discovery of HSP90 C-terminal Inhibitors and Network Pharmacological Analysis. Curr Pharm Biotechnol 2022

2. Li J.; Zuo X.; Cheng P.; Ren X.; Sun S.; Xu J.; Holmgren A.; Lu J.; The production of reactive oxygen species enhanced with the reduction of menadione by active thioredoxin reductase. Metallomics 2019,11(9),1490-1497

3. Cheng P.; Liu H.; Li Y.; Pi P.; Jiang Y.; Zang S.; Li X.; Fu A.; Ren X.; Xu J.; Holmgren A.; Lu J.; Inhibition of thioredoxin reductase 1 correlates with platinum-based chemotherapeutic induced tissue injury. Biochem Pharmacol 2020,175,113873

4. Duan D.; Feng X.; Pan D.; Wang L.; Wang Y.; Wang X.; Oridonin induces oxidative stress-mediated cancer cells apoptosis via targeting thioredoxin reductase. Curr Pharm Biotechnol 2022

5. Zhang P.; An Z.; Sun C.; Xu Y.; Zhang Z.; FLG gene mutation up-regulates the abnormal tumor immune response and promotes the progression of prostate cancer. Curr Pharm Biotechnol 2022

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