Affiliation:
1. Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University
of Medical Sciences, Tehran, Iran
2. Department of Toxicology and Pharmacology, Faculty of Pharmacy
and Pharmaceutical Sciences, Islamic Azad University, Tehran Medical Sciences University, Tehran, Iran
Abstract
Abstract:
Ovarian cancer (OC) is the 3rd common gynecologic cancer. Numerous procedures
are involved in the growth of OC, like migration, angiogenesis, proliferation, apoptosis,
invasion, and metastasis. Therefore, a better knowledge of the molecular processes
complicated in ovarian tumorigenesis can lead to better measures for the prevention and
treatment of the disease and its diagnosis. Long non-coding RNAs (LncRNAs), a subclass
of non-coding RNAs, are much more diverse than previously thought. It is suggested
that these RNAs may play a role in controlling complex cellular signaling mechanisms
via binding to proteins and influencing their function. Nevertheless, our acquaintance
with the participation of LncRNAs in the pathogenesis of OC is still restricted. Especially,
we do not yet recognize how to pharmacologically correct the epi-mutations.
Resveratrol, a natural polyphenol mostly derived from grapes, has been evaluated in
many studies to find its cancer therapeutic potential. In the current paper, we aimed to review
the role of resveratrol as a potential natural product on lncRNAs as novel diagnostic
and therapeutic targets in OC and represent new insights for further investigations.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
1 articles.
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