Affiliation:
1. Department of Neurosurgery, 5th Military Clinical Hospital with the SP ZOZ Polyclinic in Krakow, 30-901, Krakow,
Poland
2. Department of Histology, Cytophysiology and Embryology, Faculty of Medicine in Zabrze, Academy of Silesia
in Katowice, 41-800, Zabrze, Poland
Abstract
:
Degenerative disc disease of the lumbosacral spine is a very common medical problem.
An episode of sciatica occurs at least once in the life of 60-90% of the human population.
:
A phenomenon that is closely related to the process of lowering the pH of the extracellular matrix
degenerating the intervertebral disc (IVD) is the precipitation of calcium salts, especially pyrophosphate
dehydrate and hydroxyapatite.
:
In such an altered environment of the IVD, we can observe an increased influx of monocytes, macrophages,
T-lymphocytes, as well as non-immunocompetent cells, which are a source of cytokines,
e.g., tumor necrosis alpha (TNF-α), interleukin- (IL-1β, IL-8). The above-mentioned mediators of an
inflammatory condition contribute to an increase in the expression of Brain-Derived Neurotrophic
Factor (BDNF) and Glial cell Derived Neurotrophic Factor (GDNF) in mast cells and chondrocytes,
as well as to the descending transport of these mediators along the nerve endings.
:
In the process of degeneration of the IVD as a result of repeated and even slight injuries, there is
damage to the connections of the endplate of the vertebral bodies with the IVD, which results in an
impairment of the penetration of nutritional substances and water into the disc. As a consequence,
there is an overexpression of the brain-derived neurotrophic factor GDNF, as well as neuromodulin
(GAP-43) in the mast cells and chondrocytes of the IVDs, while descending transport of these mediators
along the nerve fibers is also observed.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Biotechnology
Cited by
1 articles.
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