Affiliation:
1. Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Baoding 071002, China
Abstract
Allergic diseases are one of the most prevalent diseases at present, it is imperative to understanding the pathophysiology and treatment strategies for allergic diseases. In this process, the binding of IgE and FcεRI on effector cells plays a critical role in triggering allergic reactions. However, the species specificity of the interaction between IgE and FcεRI has not been clearly explained. This review described the characteristics and the interaction mechanism in the allergic reaction of IgE and FcεRI and summarized the species specificity between IgE and FcεRI.
Funder
Hebei Provincial Department of Education Key Research Project
Hebei Province Natural Science Foundation
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Biotechnology
Reference55 articles.
1. Deng Z.; Pu X.P.; Progress in research of the targets and new drugs resisting type I hypersensitivity. Chin J New Drug 2013,22(4),417-446
2. Castillo-Arellano J.I.; Guzmán-Gutiérrez S.L.; Ibarra-Sánchez A.; Hernández-Ortega S.; Nieto-Camacho A.; Medina-Campos O.N.; Pedraza-Chaverri J.; Reyes-Chilpa R.; González-Espinosa C.; Jacareubin inhibits FcεRI-induced extracellular calcium entry and production of reactive oxygen species required for anaphylactic degranulation of mast cells. Biochem Pharmacol 2018,154,344-356
3. Yalcin A.D.; An overview of the effects of anti-IgE therapies. Med Sci Monit 2014,20,1691-1699
4. Liu Z.C.; Shi H.L.; Zhang Y.F.; Zhao L.J.; [Progress in the study of allergic disease drugs targeting on IgE/FcepsilonRI signaling pathway]. Yao Xue Xue Bao 2011,46(10),1161-1166
5. Smith L.D.; Leatherbarrow R.J.; Spivey A.C.; Development of small molecules to target the IgE:FcεRI protein-protein interaction in allergies. Future Med Chem 2013,5(12),1423-1435
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Hypersensitivity;Reference Module in Biomedical Sciences;2020