Affiliation:
1. Department of Chemistry, College of Science, Salahaddin University-Erbil, Erbil, Iraq
2. Department of Pharmaceutics,
Faculty of Pharmacy, Tishk International University, Erbil, Iraq
Abstract
Abstract:
Colorectal cancer (CRC) is considered a lethal cancer all around the world, and its incidence
has been reported to be increasing. Chemotherapeutic drugs commonly used for treating this
cancer have shown some drawbacks, including toxicity to healthy cells and non-precise delivery.
Thus, there is a necessity for discovering novel diagnostic and therapeutic options to increase the
survival rate of CRC patients. Chitosan, as a natural polymer, has attracted a lot attention during
the past years in different fields, including cancer. Studies have indicated that chitosan-based materials
play various roles in prevention, diagnosis, and treatment of cancers. Chitosan nanoparticles
(NPs) have been shown to serve as anti-cancer agents, which provide sustained drug release and
targeted delivery of drugs to the tumor site. In this paper, we review available literature on the
roles of chitosan in CRC. We discuss the applications of chitosan in designing drug delivery systems
as well as anti-cancer activities of chitosan and involved signaling pathways.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Biotechnology
Cited by
6 articles.
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