Affiliation:
1. Department of Pharmaceutics, Faculty of Pharmacy, Integral University, Lucknow, 226026, India
2. Department of
Pharmacology, Faculty of Pharmacy, Integral University, Lucknow, 226026, India
Abstract
Abstract:
Berberine (BBR) is an isoquinoline alkaloid with several therapeutic properties, including
anti-microbial, anti-diarrhea, anti-viral, anti-inflammatory, antihypertensive, anti-tumor, and
anti-diabetes. However, its low water solubility, low absorption, first-pass metabolism, nontargeting,
and poor bioavailability represent major hurdles to its successful therapeutic applications.
Hence, researchers have attempted to enhance the biological and pharmacological activity of BBR
to overcome its drawbacks by encapsulation of BBR in micro and nano delivery systems. For the
preparation of nanostructured carrier systems of BBR, a range of methods has been developed, and
each method has its benefits and characteristics. This review critically describes different types of
nanocarriers like liposomes, niosomes, ethosomes, nanoemulsions, polymeric nanoparticles, micelles,
dendrimers, and silver and gold nanoparticles that have been used for encapsulation of BBR
for different therapeutic applications. The various pharmaceutical characteristics (size, shape, entrapment
efficiency, zeta potential, drug release, and drug permeation) of these BBR-loaded nanocarriers
have been discussed systematically. Preclinical studies of BBR nanoformulations involving
animal models are also discussed.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Biotechnology
Cited by
4 articles.
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