Affiliation:
1. Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research-Raebareli, Lucknow,
U.P., 226002, India
Abstract
Abstract:
The skin being the largest organ, protects our body against harmful chemicals, pathogens,
and physical agents. It constitutes primarily three layers: epidermis, dermis, and subcutaneous
layers. Injuries occurring due to burning remain localized to the skin or other organic tissues
caused by flame, extreme heat, and close contact with chemicals or heated objects. Conventional
treatments are available for the treatment of burns; however, they are expensive and might completely
replace autologous tissue transfer. Nanotechnology-based approaches include organic nanoparticles,
dendrimers, hydrogels, etc. Biocompatibility usually refers to the ability of biomaterials
to perform their respective functions centered on medical therapy without causing any systemic
or local effects. Polymeric materials like a natural (chitosan and hyaluronic acid) and synthetic
(polylactic acid and polycaprolactone) materials are employed as biomaterials. Various preclinical
and clinical studies were performed in animal models. In this review, the authors have discussed
elaborately the biocompatible polymers, which are used in the treatment of burn wounds. Afterwards,
a brief discussion on the polymers, pre-clinical and clinical studies, and regulatory concerns
related to nanomaterials have also been covered.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Biotechnology
Cited by
6 articles.
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