Affiliation:
1. Department of Pharmaceutics, School of Pharmaceutical Education and
Research, Jamia Hamdard, New Delhi, 110062, India
2. Department of Pharmaceutics, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research
University, New Delhi, 110017, India
Abstract
Background:
The treatment of wound-associated infections has always remained a challenge
for clinicians, with the major deterring factor being microbial biofilms, majorly bacterial or
fungal. Biofilm infections are becoming a global concern owing to resistance to antimicrobials.
Various fungal pathogens form fungal biofilms, namely Candida sp., Aspergillus fumigates,
Trichosporon sp., Saccharomyces cerevisiae, Cryptococcus neoformans, among others. The rising
cases of fungal biofilm resistance add to the burden of wound care. Additionally, with an increase in
the number of surgical procedures, transplantation, and the exponential use of medical devices, the
fungal bioburden is rising.
Objectives:
The review discusses the methods of biofilm formation and the resistance mechanisms
against conventional treatments. The potential of novel delivery strategies and the mechanisms involved
therein are also highlighted. Further, the prospects of nanotechnology-based medical devices
to combat fungal biofilm resistance have been explored. Some clinical trials and up-to-date patent
technologies to eradicate biofilms are also mentioned.
Conclusion:
Due to the many challenges faced in preventing/eradicating biofilms, only a handful of
approaches have made it to the market. Eradication of fungal biofilms are a fragmentary area that
needs further exploration.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Biotechnology
Cited by
1 articles.
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