Affiliation:
1. Department of Biotechnology and Bioengineering, Institute of Advanced Research, Gandhinagar, Gujarat 382426, India
Abstract
Abstract:
The present article reports the synthesis, characterization, and antioxidant activity
of the chalcone-deoxycholic acid conjugates. The structures of the synthesised bile acidchalcone
conjugates have been determined using 1H and 13C NMR spectroscopy. According
to the results of the DPPH experiment, compounds 5e (3, 4, 5-methoxy; IC50; 15.04 μg
/ml) and 5f (4-hydroxy group; IC50; 11.73 μg /ml) had higher antioxidant activity than the
control compound ascorbic acid (IC50; 20.72 μg /ml). The best conjugate was found to be
5f in the DPPH test (IC50: 11.73 μg /ml; 4-hydroxy group), while the best conjugate in the
ABTS assay was found to be 5g (IC50: 67.97 μg /ml; pyridine group). It is straightforward
to synthesize a huge library of bile acid-derived compounds and employ them in comprehensive
structure-activity relationship investigations to identify the compounds with the
best antioxidant activity.
Publisher
Bentham Science Publishers Ltd.
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