Affiliation:
1. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif
21944, Saudi Arabia
2. Department of Pharmaceutical Chemistry, Era College of Pharmacy, Era University, Lucknow, 226003, Uttar
Pradesh, India
Abstract
Abstract:
In many significant bioactive heterocyclic compounds, the six-membered ring
pyrimidines play a major role as bioactive components. There is a lot of room for innovation
in the fields of medicinal chemistry and the chemical industries because of the numerous
pyrimidine synthesis methods and their varied reactions. The pharmacological effects of
pyrimidine derivatives include anticonvulsant, antibacterial, antifungal, antiviral, antitubercular,
anticancer, antimicrobial, antihypertensive, antiulcer, anti-inflammatory, antimalarial,
antioxidant, analgesic, sedative, anti-depressive, antipyretic properties, etc. The synthetic
adaptability of pyrimidine has made it possible to create a wide range of structurally
different analogs, including analogs from substitution on the pyrimidine ring at various
places, which has aided the design of a wide variety of therapeutic targets. This review's goal
is to examine the pharmacological effects of numerous pyrimidine derivatives. This review provides an overview
of pyrimidine compounds for biological activities and examines the novel pharmacological molecules containing
pyrimidine rings in the future.
Publisher
Bentham Science Publishers Ltd.
Reference140 articles.
1. Campbell I.B.; Macdonald S.J.F.; Procopiou P.A.; Medicinal chemistry in drug discovery in big pharma: Past, present and future. Drug Discov Today 2018,23(2),219-234
2. Dinakaran V.S.; Bomma B.; Srinivasan K.K.; Fused Pyrimidines: The heterocycle of diverse biological and pharmacological significance. Pharma Chem 2012,4(1),255-265
3. Arora P.; Arora V.; Lamba H.S.; Wadhwa D.; Importance of heterocyclic chemistry: A review. Int J Pharm Sci Res 2012,3(9),2947-2954
4. Tiwari K.; Dubey V.K.; Fresh insights into the pyrimidine metabolism in the trypanosomatids. Parasit Vectors 2018,11(1),87
5. Mahapatra A.; Prasad T.; Sharma T.; Pyrimidine: a review on anticancer activity with key emphasis on SAR. Future. J Pharm Sci 2021,7(1),123
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