Affiliation:
1. Aix Marseille Univ, CNRS, Centrale Marseille, iSm2, Marseille, France
Abstract
Abstract:
The Nazarov reaction involves the cyclization of divinyl ketones into cyclopentenones
under the influence of strong acids. The prevalence of five-membered carbocycles
in a multitude of natural and bioactive products has triggered an intense development of
efficient methods for their construction. In particular, asymmetric versions of the Nazarov
reaction are achieved by using either a chiral auxiliary or a chiral catalyst, which can be an
organocatalyst, a metal catalyst, or a multicatalytic system. This review aims to update the
field of asymmetric Nazarov reactions published since 2017. It is divided into four sections,
dealing successively with Nazarov reactions of chiral auxiliaries, organocatalytic
enantioselective Nazarov reactions, metal/boron-catalyzed enantioselective Nazarov reactions,
and multicatalytic enantioselective Nazarov reactions. Each section of the review is
subdivided into simple asymmetric Nazarov reactions and Nazarov-based domino/tandem reactions, which
have allowed numerous more complex functionalized chiral molecules to be synthesized in one-pot procedures.
Publisher
Bentham Science Publishers Ltd.
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