Author:
Kahn David,Mittelstaedt Daniel,Matyas John,Qu Xiangui,Lee Ji Hyun,Badar Farid,Les Clifford,Zhuang Zhiguo,Xia Yang
Abstract
Background:
The predictable outcome of the anterior cruciate ligament transection (ACLT) canine model, and the similarity to naturally occurring osteoarthritis (OA) in humans, provide a translatable method for studying OA. Still, evidence of direct meniscus-induced cartilaginous damage has not been identified, and gross-anatomical blinded scoring of early-stage OA has not been performed.
Objective:
A gross anatomical observation and statistical analysis of OA progression to determine meniscus induced cartilaginous damage, to measure the macroscopic progression of OA, and to address matters involving arthroscopic and surgical procedures of the knee.
Method:
Unblinded assessment and blinded scoring of meniscal, tibial, femoral, and patellar damage were performed for control and at four time points following unilateral ACLT: 3-week (N=4), 8-week (N=4), 12-week (N=5), and 25-week (N=4). Mixed-model statistics illustrates damage (score) progression; Wilcoxon rank-sum tests compared time-point scores; and Wilcoxon signed-rank tests compared ACLT and contralateral scores, and meniscus and tibia scores.
Result:
Damage was manifest first on the posterior aspect of the medial meniscus and subsequently on the tibia and femur, implying meniscal damage can precede, coincide with, and aggravate cartilage damage. Damage extent varied chronologically and was dependent upon the joint component. Meniscal damage was evident at 3 weeks and progressed through 25-weeks. Meniscal loose bodies corresponded to tibial cartilage damage location and extent through 12 weeks, followed by cartilage repair activity after complete meniscal degeneration.
Conclusion:
This study provides additional information for understanding OA progression, identifying OA biomarkers, and arthroscopic and meniscectomy procedures.
Publisher
Bentham Science Publishers Ltd.
Reference45 articles.
1. Adams ME, Brandt KD.
Hypertrophic repair of canine articular cartilage in osteoarthritis after anterior cruciate ligament transection.
J Rheumatol
1991;
18
(3)
: 428-35.
2. Brandt KD, Braunstein EM, Visco DM, OConnor B, Heck D, Albrecht M.
Anterior (cranial) cruciate ligament transection in the dog: a bona fide model of osteoarthritis, not merely of cartilage injury and repair.
J Rheumatol
1991;
18
(3)
: 436-46.
3. Setton LA, Mow VC, Müller FJ, Pita JC, Howell DS.
Mechanical properties of canine articular cartilage are significantly altered following transection of the anterior cruciate ligament.
J Orthop Res
1994;
12
(4)
: 451-63.
[http://dx.doi.org/10.1002/jor.1100120402] [PMID: 8064477]
4. Brandt KD.
Transection of the anterior cruciate ligament in the dog: a model of osteoarthritis.
Semin Arthritis Rheum
1991;
21
(3)
(Suppl. 2)
: 22-32.
5. Cook JL, Kuroki K, Visco D, Pelletier JP, Schulz L, Lafeber FP.
The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the dog.
Osteoarthritis Cartilage
2010;
18
(Suppl. 3)
: S66-79.
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