Affiliation:
1. Department of Transdisciplinary Research, Lovely Professional University, Phagwara, Punjab-144411, India
Abstract
The bacterial infection is one of the major health issues throughout the world. To protect
humans from the infection and infectious agents, it is important to understand the mechanism of interaction
of pathogens along with their susceptible hosts. This will help us to develop a novel strategy
for designing effective new drugs or vaccines. As iron is an essential metal ion required for all
the living systems for their growth, as well, it is needed by pathogenic bacterial cells for their
growth and development inside host tissues. To get iron from the host tissues, microbes developed
an iron-chelating system called siderophore and also corresponding receptors. Siderophores are
low molecular weight organic complex produced by different strains of bacteria for the procurement
of iron from the environment or host body under the iron deficient-conditions. Mostly in the
environment at physiological pH, the iron is present in the ferric ionic form (Fe3+), which is water-
insoluble and thus inaccessible for them. Such a condition promotes the generation of
siderophores. These siderophores have been used in different areas such as agriculture, treatment
of diseases, culture the unculturable strains of bacteria, promotion of plant growth, controlling phytopathogens,
detoxification of heavy metal contamination, etc. In the medical field, siderophores
can be used as “Trojan Horse Strategy”, which forms a complex with antibiotics and also delivers
these antibiotics to the desired locations, especially in antibiotic-resistant bacteria. The promising
application of siderophore-based use of antibiotics for the management of bacterial resistance can
be strategies to be used.
Publisher
Bentham Science Publishers Ltd.
Subject
General Health Professions
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