Sorbinil, an Aldose Reductase Inhibitor, in Fighting Against Diabetic Complications
Author:
Huang Qi1, Liu Qiong2, Ouyang Dongsheng1
Affiliation:
1. Department of Clinical Pharmacology, Xiangya Hospital of Central South University, Changsha 410008, China 2. Department of Oncology, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China
Abstract
Background:
Aldose reductase (AR) is involved in the pathogenesis of diabetes, which
is one of the major threats to global public health.
Objective:
In this review article, we have discussed the role of sorbinil, an AR inhibitor (ARI), in
preventing diabetic complications.
Results:
AR contributes in diabetes by generating excess intracellular superoxide and other mediators
of oxidative stress through polyol pathway. Inhibition of AR activity thus might be a potential
approach for the management of diabetic complications. Experimental evidences indicated that
sorbinil can decrease AR activity and inhibit polyol pathway. Both in vitro and animal model studies
reported the efficacy of sorbinil in controlling the progression of diabetes. Moreover, Sorbinil
has been found to be comparatively safer than other ARIs for human use. But, it is still in earlyphase
testing for the treatment of diabetic complications clinically.
Conclusion:
Sorbinil is an effective ARI, which could play therapeutic role in treating diabetes
and diabetic complications. However, advanced clinical trials are required for sorbinil so that it
could be applied with the lowest efficacious dose in humans.
Funder
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
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